CRISPR/shRNA Library Products

Functional genome screening include whole genome library, cancer focus pathway library, drug resistance synthetic lethal target library, etc., which can be customized on demand (according to customer pathway, drug or disease model, such as immunity, metabolism, membrane protein, etc.), support lentivirus packaging and plasmid delivery, and provide supporting data analysis and interpretation services.

TRiC Platform Combo Package

TRICBIO in situ target screening toolkit is suitable for organoids, PDX and in situ tumor animal models, providing a combination of standardized infection systems, optimized reagents for screening processes, and supporting data analysis and interpretation services.

Preclinical Development Pipeline

Relying on the organ 2.0 modeling system, functional genomics screening platform and TRiC in situ verification platform, Zewei Bio continues to promote the functional verification and drug evaluation of multiple tumor directions around new targets and mechanisms of action. Our development focuses on the early breakthrough of "from 0 to 1", with special attention to functional targets, in vivo specific regulatory factors, immune microenvironment regulatory nodes, etc. that are difficult to find by traditional multi-omics methods. A number of new target candidate molecules have been validated in vitro and entered the in vivo evaluation phase. We actively seek cooperative development, transfer authorization and other forms of strategic cooperation, and welcome industry partners to work with us to accelerate the pipeline to create truly clinically transformable differentiated new drugs.

Organoid Modeling Services

TRICBIO provides organoid modeling services based on primary tumor tissues, supporting modular customization including PDO 1.0/2.0 modeling, PBMC co-culture, drug sensitivity testing, and other tailored modules. Our deliverables include SOPs for the culture process, organoid formation images, passage stability data, and drug sensitivity testing results.

Immune/CAF Co-culture System

Immune activation system contains CD3/CD28 antibody and IL-2 and other cytokines; the CAF co-culture system includes TGF-β, IL-6 and other microenvironmental factors, which supports the study of immune infiltration, matrix interference, drug-microenvironment synergistic effect. It is suitable for organoid PBMC co-culture experiments and supports the evaluation of killing effect.

Organoid Chip and High-Throughput Screening Platform

Based on microfluidic and chip platform, the organoid chip supports high-throughput drug screening, immune cell infiltration observation and drug efficacy imaging evaluation. It can realize multi-well bit parallel detection, which is suitable for large-scale drug screening and mechanism exploration.

Blood-Brain Barrier Organoid Model

A central nervous system (CNS) barrier-mimicking organoid co-culture system was developed by integrating brain endothelial cells, astrocytes, and brain organoids, enabling applications in drug permeability assessment, transport mechanism studies, and CNS target validation.

Vascularized Organoid Model

The co-culture system of fusion tumor organoids and human vascular endothelial cells can form a vascular-like lumen structure, which can be used to simulate tumor progression, drug distribution and vascular target mechanism research in the microenvironment of blood supply.

For customized research/target development services, please contact TRiCBiO Team. We will provide you with professional, efficient and reliable one-stop support.