New Target Discovery and Validation Services

We can provide integrated services from genome-wide screening to target evaluation and validation, suitable for small molecules, ADC, dual Antibodies, PROTAC and other types of original drug target exploration.

1 Services include:

•  CRISPR/shRNA positive and negative screening (cell Lines, organoids, animals)

•  Target scoring model and hit validation

•  Mechanism research and pathway analysis-functional verification of known 

•  Targets and upstream and downstream expansion

2 Applications:

•  New target discovery                             •  Synthetic lethal targets

•  Combination therapy targets                 •   Immune regulatory factors, etc.

Organoid Modeling and Drug Screening Service

Based on a self-established library of over 1,500 patient-derived organoid models, we provide clients with clinically relevant services such as drug sensitivity testing, drug screening, and drug efficacy validation.

1 Services include:

•  PDO1.0 & 2.0 Organoid Modeling

•  Drug single drug/combination efficacy evaluation (IC50, AUC, etc.)

•  Individualized drug susceptibility assessment (assisted by precision medication)

•  Drug mechanism research: immune co-culture, immune depletion models

2 Applications:

•  Target drug evaluation

•  Individualized efficacy prediction

•  Clinical medication guidance

•  Multi-target drug screening

In-Situ TRiC Functional Screening Service

The TRiC platform supports in situ target screening and mechanistic studies across primary tumor tissues/organoids/animal models, preserving the complex microenvironment context.

1 Services include:

•  Primary tissue/organoid virus infection, CRISPR interference

•  In situ drug treatment and phenotype screening

•  High-throughput sequencing and target scoring

•  Multi-omics integration analysis and target evaluation report generation

2 Applications:

•  Target discovery for high-throughput applications

•  Exploration of immune targets 

•  Challenges such as target screening in the context of drug    resistance

Customer Support and Cooperation Model

Innovative pharmaceutical companies: Early target discovery, preclinical mechanism research, auxiliary pipeline decision-making

Scientific research units: Project cooperation, article publication, project mechanism research support

Hospital/translational medicine center: Individualized drug susceptibility testing and precise treatment evaluation

AI drug development company: Provides realistic model platform and biometric verification tools

Technical Services:Commissioned experimental design and execution, delivery of complete results and analysis reports

Data analysis: Existing data analysis support, delivery of analysis reports and visual charts

Platform: Co-develop models or targets with pharmaceutical companies and laboratories, establish shared databases or dedicated service lines

Joint development: Deep collaborative target screening and drug development (patent co-holding or results transformation cooperation)

For customized research/target development services, please contact TRICBIO Team. We will provide you with professional, efficient and reliable one-stop support.