Model & assay dataCase study

Breast cancer PDO: phenotype & tissue identity

Explore breast cancer PDO tissue and subtype features through matched histology, ER and Ki67 profiling to guide model selection and candidate studies.

Model & sampleBreast cancer PDO with source-tissue comparison

Study setupModel identity and baseline characterization

AssaysBright-field, H&E, DAPI, ER and Ki67

SUBTYPE & TISSUE IDENTITY

Define subtype and tissue identity

DAPI, ER and Ki67 staining in a breast cancer PDO — 01
Receptor and proliferation features: ER labels estrogen-receptor-associated signal, Ki67 labels proliferating cells and DAPI labels nuclei.
Model & assay data

STUDY EVIDENCE

Source tissue, PDO morphology and histology

Source-tissue H&E, PDO bright-field and PDO H&E compare tissue and culture morphology.

01Source tissue

Source-tissue H&E morphology

Source-tissue H&E provides the reference for PDO morphology.

02Culture morphology

PDO structure in 3D culture

Bright-field imaging shows PDO morphology in 3D culture.

03PDO histology

Tissue structure in the PDO section

PDO and source-tissue H&E compare tissue structure and cell morphology.

View study figure set

Breast-cancer source-tissue and PDO morphology figure set

Compare source-tissue H&E, PDO bright-field and PDO histology to view the breast cancer model’s morphological features together.

Study application

Source-tissue and PDO morphology establish a histological reference. Receptor, target and functional profiling can then guide model selection for candidate studies.

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