Evidence & resources
Evidence for your study
See images and assay results from model characterization, drug-response, safety and immune studies. Find the models and study options that fit your project.
Find relevant cases, model characterization and technical resources by project goal, organ or content type.
Showing 9 of 26 resources
Immune signals and treatment response in PDO 2.0
Separate clear-cell renal cell carcinoma (ccRCC) and non-small-cell lung cancer (NSCLC) studies show tissue images, immune-related signals and post-treatment flow readouts for immunotherapy research.
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Antibody distribution and ADC response in breast PDOs
Explore two breast PDO studies: antibody distribution in frozen sections, and morphology and viability after ADC treatment.
Explore the study data ↗ALI-PDO white paper: principles, applications & study design
Explore ALI-PDO biology, model selection and assay design for tissue, immune and treatment-response studies.
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Kidney organoids for safety and injury research
Investigate drug-related kidney injury through cisplatin-associated molecular changes and time-course imaging after doxorubicin exposure.
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Human intestinal organoid IBD-like inflammation study
See how human intestinal organoids capture IBD-like inflammation and candidate response through morphology, barrier permeability and IL-8 readouts.
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Colorectal cancer PDO 2.0: tissue & immune profiling
Compare source tissue and PDO images to see tissue architecture, epithelial features and immune-cell context in colorectal cancer PDO 2.0.
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NSCLC PDO 2.0: immune baseline & IL-2 comparison
CD4/CD8 T-cell counts across IL-2 conditions show immune baseline and condition-related differences in non-small-cell lung cancer (NSCLC) PDO 2.0 samples.
Explore the case and results ↗How an organoid project discussion begins
Begin with non-confidential context so the scientific team can understand the objective, identify suitable models and assays, and prepare a project outline.
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Normal lung organoids: identity and LPS injury
Explore normal lung organoids for pulmonary safety and candidate evaluation through airway and alveolar profiling, tissue imaging and inflammatory injury studies.
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Adjacent non-tumor liver organoids
Explore the culture and epithelial features of adjacent non-tumor liver organoids for tissue comparison, epithelial biology and drug-exposure studies.
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Mesenchymal tumor organoid development
Explore two separate GIST and osteosarcoma studies through culture images, pathology and tissue–PDO marker comparisons.
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PDOX: organoid-to-in vivo validation
Define when a PDO program should extend into PDOX and how model identity, in vivo growth, histology and efficacy are evaluated together.
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Breast cancer PDO: phenotype & tissue identity
Explore breast cancer PDO tissue and subtype features through matched histology, ER and Ki67 profiling to guide model selection and candidate studies.
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Renal cancer PDO 2.0: apoptosis & immune response
Compare targeted, immune and combination treatments in renal cancer PDO 2.0 through histology, apoptosis and T-cell analysis.
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PDAC PDO 2.0: epithelial identity & immune readouts
Explore tissue architecture, epithelial features and T-cell profiling in PDAC PDO 2.0 for tumor and immune-related research.
Explore the case and results ↗PDO 1.0 vs PDO 2.0: choosing a culture system
Compare the biology each culture system can preserve and measure, then select or combine them around mechanism, endpoints and sample context.
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PUBLISHED GRAPHICAL ABSTRACTALI tumor–immune organoids | Platform & programs
Explore the science behind ALI tumor–immune organoids and its applications in sample profiling, immunotherapy evaluation and functional assays.
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Endometrial organoid profiling
Follow growth and stage-related changes in human endometrial organoids, with epithelial marker profiling to support reproductive biology and drug research.
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Multi-organoid culture and tissue comparison
Explore culture and tissue features across organoid models to find options suited to your research goal.
Explore the case and results ↗Choosing among organoid, 2D and PDX models
Compare 2D, organoid and PDX models by biological context, timing and throughput to choose the system that best fits the program goal.
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HCC PDO and PDO 2.0: culture format and tissue identity
Compare HCC PDO and PDO 2.0 culture morphology alongside source-tissue and marker images to examine model tissue features.
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Liver cancer PDO 2.0: morphology and tissue identity
Culture and source-tissue images, together with hepatic and endothelial marker results, show tissue features of liver cancer PDO 2.0.
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Normal gastric organoids: culture & histology
Explore normal gastric organoids for epithelial biology and drug studies through growth imaging, histology, proliferation and mucin-related profiling.
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ADC distribution & efficacy in organoids
Plan ADC distribution imaging and efficacy readouts, with optional whole-organoid imaging or quantitative penetration analysis.
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Glioma PDO 2.0: tumor features and treatment response
Tissue–PDO comparisons and lineage markers, plus CD31 and treatment readouts from a separate glioma study, show the model and functional data available for research.
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Normal lung and kidney organoids for safety studies
Separate normal lung and kidney studies show organ identity and injury responses, helping select safety endpoints suited to each organ and candidate.
Read the application note ↗Continue with more case studies, research resources and project guides.
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