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Model & assay dataModel characterization

Normal lung organoids: identity and LPS injury

Explore normal lung organoids for pulmonary safety and candidate evaluation through airway and alveolar profiling, tissue imaging and inflammatory injury studies.

STUDY EVIDENCE

From lung phenotypes to an LPS injury study

Alveolar and airway profiling alongside serial morphology and AT1/AT2 readouts under LPS exposure.

01Alveolar
Alveolar organoid morphology and ATII-associated LysoTracker signal

Alveolar organoid morphology and ATII-associated LysoTracker signal

Bright-field, DAPI, LysoTracker and merged views show alveolar morphology and ATII-associated acidic-organelle signals.

02Airway
SCGB1A1 (CC10), KRT5 and merged signals

SCGB1A1 (CC10), KRT5 and merged signals

SCGB1A1 (CC10) and KRT5 immunofluorescence show club- and basal-cell-associated signals.

03LPS injury | serial morphology
Control and LPS observations on days 1, 5 and 7

Control and LPS observations on days 1, 5 and 7

Day 1, 5 and 7 bright-field images compare control and LPS conditions.

04LPS injury | alveolar readouts
AT1/AT2 profiling under normal and LPS conditions

AT1/AT2 profiling under normal and LPS conditions

Bright-field, AT1, AT2, DAPI and merged views compare alveolar features under normal and LPS conditions.

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