Biobank中文Project inquiry
ApplicationsNavigation menu
R&D ServicesModels & ProductsApplicationsTechnologyEvidence & ResourcesHow We WorkAbout TRiCBIONews & EventsBiobankProject inquiry中文

Applications

Organoids for target discovery & drug R&D

Choose organoid models and assays for target discovery, efficacy and safety studies.

By therapeutic modalityBy study goalTarget discovery & functional genomics ↗

MODALITIES

By therapeutic modality

Start from how the candidate works, then select the model, controls and readouts that best test the mechanism.

5 application areas
Organoid study design for antibodies, multispecifics and TCEs from target and model selection to functional endpointsAntibody, multispecific and TCE study design01

Antibodies, multispecifics & TCEs

Compare antibody, multispecific and TCE responses in human tumor organoids, using target expression and immune activation to explain differences.

↗ADC-associated morphology and dose response in two breast cancer PDO modelsBreast cancer PDOs · ADC morphology and dose response02

ADC

Compare ADC candidates in human organoids using target-expression, tissue-distribution and activity readouts, with dedicated studies of bystander killing.

↗PanCK, CD3 and DAPI immunofluorescence in clear-cell renal cell carcinoma tissue and PDO 2.0 culturesccRCC PDO 2.0 · T cells and tissue context03

Immunotherapy

Use PDO 2.0 / ALI and project-relevant immune assays to study relationships among immune composition, architecture and treatment response.

↗Tumor-cell killing readouts in glioma PDO 2.0 across inhibitor concentrationsGlioma PDO 2.0 · inhibitor dose-related killing04

Small molecules & targeted therapy

Compare small-molecule dose responses and combinations in human organoids, with mechanistic assays to investigate differences across models.

↗Organoid genetic-perturbation workflow from model selection to functional validation05

Cell & gene therapy

Study gene delivery, genetic perturbation or therapeutic-cell function in human organoids, with models and assays matched to your therapy.

↗

QUESTIONS

By study goal

Start with target discovery, safety, delivery or biomarker questions, then combine the models and readouts needed to answer them.

4 application areas
Organoid target discovery from genetic library screening and hit confirmation to functional validation and target prioritization01

Organoid target discovery & functional genomics

Discover genetic dependencies through library screening in PDO 1.0 and PDO 2.0. Validate targets through tumor, microenvironment and treatment-response readouts.

↗Human kidney organoid bright-field morphology before and 24/48 hours after doxorubicin exposure02

Safety & toxicology

Use human organ models to compare dose- and exposure-related injury with organ-specific morphological, functional and molecular readouts.

↗Barrier and IL-8 quantitative readouts in human intestinal organoids03

Drug delivery & barrier permeability

Start with the target tissue’s barrier structure, develop permeability readouts for the project, then study candidate transport or retention.

↗Relative organoid area across vehicle, tofacitinib and candidate armsHuman intestinal organoids · area response after treatment04

Disease mechanism & biomarkers

Compare tissue images, functional assays and molecular results across models or treatments to identify biomarker candidates for follow-up validation.

↗
Evaluate one candidate across efficacy, immune response, mechanism and safety

Share your modality, mechanism and program priorities; our scientists will recommend which studies to combine and how to sequence them.

Plan your study