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Organoids for target discovery & drug R&D

Choose organoid models and assays for target discovery, efficacy and safety studies.

By therapeutic modalityBy development questionTarget discovery & functional genomics ↗

MODALITIES

By therapeutic modality

Start from how the candidate works, then select the model, controls and readouts that best test the mechanism.

5 application areas
Organoid study design for antibodies, multispecifics and TCEs from target and model selection to functional endpointsAntibody, multispecific and TCE study design01

Antibodies, multispecifics & TCEs

Evaluate target expression, effector-cell conditions, dynamic killing and immune activation together in human 3D tumor models.

↗ADC-associated morphology and dose response in two breast cancer PDO modelsBreast cancer PDOs · ADC morphology and dose response02

ADC

Compare ADC candidates in human organoids using target-expression, tissue-distribution and activity readouts, with dedicated studies of bystander killing.

↗PanCK, CD3 and DAPI immunofluorescence in clear-cell renal cell carcinoma tissue and PDO 2.0 culturesccRCC PDO 2.0 · T cells and tissue context03

Immunotherapy

Use PDO 2.0 / ALI and project-relevant immune assays to study relationships among immune composition, architecture and treatment response.

↗Tumor-cell killing readouts in glioma PDO 2.0 across inhibitor concentrationsGlioma PDO 2.0 · inhibitor dose-related killing04

Small molecules & targeted therapy

Compare candidates across doses, time points and combinations in models selected for the target and indication, using mechanism-linked readouts to explain differences.

↗Organoid genetic-perturbation workflow from model selection to functional validation05

Cell & gene therapy

Use human organoids for gene delivery, genetic perturbation and co-culture studies with therapeutic cells, with functional, mechanistic and safety readouts matched to the program.

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QUESTIONS

By development question

Start with target discovery, safety, delivery or biomarker questions, then combine the models and readouts needed to answer them.

4 application areas
Organoid target discovery from genetic library screening and hit confirmation to functional validation and target prioritization01

Organoid target discovery & functional genomics

Use genetic-library screening, gene-dependency discovery and functional validation across PDO 1.0 and PDO 2.0 to connect tumor-intrinsic biology, microenvironmental function and treatment response.

↗Human kidney organoid bright-field morphology before and 24/48 hours after doxorubicin exposure02

Safety & toxicology

Use human organ models to compare dose- and exposure-related injury with organ-specific morphological, functional and molecular readouts.

↗Barrier and IL-8 quantitative readouts in human intestinal organoids03

Drug delivery & barrier permeability

Establish barrier structure and permeability as the study baseline, then design transport and retention studies for the candidate and its delivery format.

↗Relative organoid area across vehicle, reference treatment and candidate armsHuman intestinal organoids · inflammatory and barrier readouts04

Disease mechanism & biomarkers

Interpret tissue-level, functional and molecular changes in the context of the model and treatment to identify reproducible, testable signals for R&D decisions.

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Evaluate one candidate across efficacy, immune response, mechanism and safety

Share your modality, mechanism and program priorities; our scientists will recommend which studies to combine and how to sequence them.

Plan your study