Application
Cell & gene therapy studies
Study gene delivery, genetic perturbation or therapeutic-cell function in human organoids, with models and assays matched to your therapy.
- Model choiceSelect the organoid model for the study
- DeliverySet delivery and expression conditions
- Gene perturbationPlan knockdown or overexpression
- AssessmentConfirm molecular change and model state
- Functional readoutsCompare phenotype and treatment response
Two study approaches
Two paths for cell and gene therapy
Choose gene delivery and perturbation studies or therapeutic-cell co-cultures. Match the model and functional, mechanistic and safety assays to your therapy.
STUDY IMAGES
HCC organoid delivery and expression
Day-3 images compare lentiviral expression and morphology in control and lncRNA shRNA conditions. Follow-on assays can assess molecular changes, function and treatment response.
View imageBright-field and green fluorescence overlay showing organoid morphology and expression in the control condition.
Delivery and expression imaging
View imageOrganoid morphology and expression at the same time point, shown alongside the control condition.
Delivery and expression imagingStudy focus
Questions we can help answer
- 01How does the proposed delivery or genetic perturbation perform in the target model?
- 02What functional phenotype does the intervention produce?
- 03When should organ-safety readouts be added?
Study workflow
From study goal to results
Vector, cell and model setup
Define vector or cell format, target cell, model integrity and key assay endpoints.
Delivery and expression assessment
Assess entry, expression, perturbation performance and model tolerance under defined conditions.
Function and mechanism
After establishing delivery and perturbation performance, assess the intended phenotype, pathway and durability.
Safety and sample expansion
Add normal-tissue, inflammatory or off-target readouts around the mechanism, then plan work in additional samples.
Model options
Models for your study
Co-development aligns delivery, perturbation performance, model QC and functional endpoints, then extends the results into mechanism or safety studies.
PROJECT DISCUSSION
Plan a cell or gene therapy study
Vector or cell format, target tissue and intended functional phenotype guide model selection, perturbation assessment and safety readouts.