01Source tissue
Source-tissue H&E reference
Source-tissue H&E shows epithelial, glandular and stromal context.
Model & assay dataCase study
Colorectal cancer PDO 2.0: tissue & immune profiling
Compare source tissue and PDO images to see tissue architecture, epithelial features and immune-cell context in colorectal cancer PDO 2.0.
Model & sampleConventional colorectal PDO morphology with PDO 2.0 tissue and immune profiling
Study setupModel identity and baseline characterization
AssaysBright-field, H&E, CD3, CD20, Pan-CK and Ki67
STUDY EVIDENCE
Tissue reference and PDO 2.0 immune profiling
Conventional PDO morphology alongside PDO 2.0 tissue, epithelial and immune profiling.
Conventional PDO | morphology and histology3 study figures
02Culture morphology
3D culture morphology of a colorectal cancer PDO
Bright-field imaging shows colorectal PDO morphology and culture state.
03PDO histology
Epithelial structure in the PDO section
PDO and source-tissue H&E compare epithelial and tissue structures.
PDO 2.0 | tissue and immune profiling1 study figure
04PDO 2.0 profiling
Source-tissue and PDO 2.0 histology and immune profiling
Source-tissue and PDO 2.0 H&E and DAPI/CD20/CD3 images are compared alongside Pan-CK, Ki67 and CD3 profiling of epithelial, proliferative and immune features.
Study application
Tissue morphology, epithelial markers and immune profiling establish the model baseline for colorectal efficacy, immunotherapy and mechanism studies.
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