Human intestinal organoid IBD-like inflammation study
See how human intestinal organoids capture IBD-like inflammation and candidate response through morphology, barrier permeability and IL-8 readouts.
Reference drug & candidate
Morphological response to treatment
Organoid projected area was higher with tofacitinib and the candidate than with vehicle.
Select an image to view in detail ↗
One representative field per arm, normalized to its own day-0 area. Projected area describes morphology, rather than cell viability or comparative efficacy.
HUMAN IBD-LIKE STUDY
Barrier and IL-8 changes in the inflammation model
FITC-Dextran and IL-8 readouts characterize barrier and secretory changes under inflammatory conditions.
View imageBarrier readout | FITC-positive area in matched fields: 0.023% control, 0.944% challenged. One representative field per group.
Study data
View imageBarrier and inflammatory readouts | FITC-positive area and mean IL-8 rose under inflammatory conditions. FITC uses matched representative fields; IL-8 has three measurements per condition.
Study dataEngineered Matrices Enable the Culture of Human Patient-Derived Intestinal Organoids
This peer-reviewed study describes engineered matrices for culturing human patient-derived intestinal organoids and complements the inflammation and barrier assays used in sample-tailored IBD studies.
Related models and services
Explore related models and services
PROJECT DISCUSSION
Discuss a study for your program
Tell us which model features and readouts matter most. Our scientists will recommend the model, QC plan and study endpoints.