01Model confirmation
Tumor tissue, PDO bright-field and PDO H&E
Tumor-tissue H&E, PDO bright-field and PDO H&E establish the pretreatment histological reference.
Study resultsCase study
Renal cancer PDO 2.0: apoptosis & immune response
Compare targeted, immune and combination treatments in renal cancer PDO 2.0 through histology, apoptosis and T-cell analysis.
Model & sampleRenal cancer PDO 2.0 with source-tissue comparison
Study setupTargeted, immune and combination conditions configured for the study
AssaysH&E, Annexin V/PI and CD3/CD8 flow cytometry
STUDY EVIDENCE
Integrated evaluation of model identity, apoptosis and immune change
Histology establishes model context; flow readouts compare cell-death and T-cell changes across treatments.
Study application
Pair Annexin V/PI and CD3/CD8 results from the same treatment conditions to compare cell-death and immune changes and select mechanism endpoints for the candidate.
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PROJECT DISCUSSION
Discuss a study for your program
Tell us which model, assay or finding you want to extend. Our scientists will adapt the approach to your candidate, samples and decision point.