01Normal lung | alveolar
Alveolar organoid morphology and ATII-associated LysoTracker signal
Bright-field, DAPI, LysoTracker and merged views show alveolar morphology and ATII-associated acidic-organelle signals.
Model & assay dataApplication note
Normal lung and kidney organoids for safety studies
Separate normal lung and kidney studies show organ identity and injury responses, helping select safety endpoints suited to each organ and candidate.
Model & sampleNormal lung and human kidney organoids, with kidney model source and culture approach selected for each study
Study setupLPS lung-injury conditions and kidney drug-injury studies inform organ-specific exposure and control design for a new candidate
AssaysLung: serial morphology, AT1/AT2, ATII-associated LysoTracker signal, SCGB1A1 (CC10) and KRT5; kidney: Nephrin/LTL-associated identity profiling and a doxorubicin injury time course
STUDY EVIDENCE
Lung and kidney organoids for safety studies
Separate lung and kidney studies show organ identity and injury responses.
Normal lung: identity and LPS injury4 study figures
02Normal lung | airway
SCGB1A1 (CC10) and KRT5 airway-cell signals
SCGB1A1 (CC10) and KRT5 immunofluorescence show club- and basal-cell-associated signals.
03Normal lung | LPS injury window
Serial morphology under control and LPS conditions
Day 1, 5 and 7 bright-field images compare control and LPS conditions.
04Normal lung | alveolar endpoints
AT1/AT2 profiling under normal and LPS conditions
Bright-field, AT1, AT2, DAPI and merged views compare alveolar features under normal and LPS conditions.
Human kidney organoids: model characterization2 study figures
05Normal kidney | morphology
Whole-organoid and local kidney structures
Bright-field and inset views show whole-organoid and local kidney structures.
06Normal kidney | nephron identity
Nephrin- and LTL-associated immunofluorescence
Nephrin and LTL immunofluorescence show podocyte- and tubule-associated features.
Human kidney study: doxorubicin acute-injury observation1 study figure
07Injury study | observation window
Morphology before and 24/48 hours after doxorubicin exposure
Bright-field images before and 24 and 48 hours after doxorubicin exposure show changes in kidney organoid morphology.
Study application
Separate lung and kidney studies show organ-specific identity and injury endpoints that can guide complementary safety evaluations for the same candidate.
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