Solutions & R&D services
Disease models for collaborative research
Use established IBD assay methods or tailor ADPKD, blood–brain barrier and other disease models for mechanistic research and scientific collaboration.
Discovery research
Discovery & validation
Test whether genetic or pharmacologic target perturbation produces the expected phenotype and pathway changes in a relevant human organoid model.
PDO 1.0 + PDO 2.0 · genetic-library screening01Organoid target discovery & functional genomics
Use genetic-library screening, gene-dependency discovery and functional validation across PDO 1.0 and PDO 2.0 to connect tumor-intrinsic biology, microenvironmental function and treatment response.
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02Target validation & mechanism studies
Determine how target modulation changes disease-relevant phenotypes, molecular pathways and treatment response in human organoid models.
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Human intestinal organoid · inflammation & barrier03Mechanism & biomarkers
Relate tissue, functional and molecular changes to the observed phenotype and identify response-associated biomarker candidates for further validation.
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04Custom model development
Develop a model and assay plan for specialized tissues, rare diseases or complex co-cultures, starting from the samples and endpoints available to your program.
↗Safety & drug delivery
Safety & drug delivery
Assess organ injury and exposure-dependent response windows, then develop barrier-permeability or candidate-transport assays for the relevant tissue system.
Human intestinal organoid · inflammation & barrierDISEASE MODELS
Disease models for collaborative research
Start with inflammatory barrier biology, inherited kidney disease or neurovascular-barrier questions, then use model characterization to guide mechanism studies, method development or custom conditions.
Human intestinal organoid IBD-like inflammation model
Study IBD-like inflammation in human intestinal organoids through morphology, FITC-Dextran, IL-8 and image-based candidate readouts.
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Tailored ADPKD organoid cyst-phenotype studies
For autosomal dominant polycystic kidney disease (ADPKD), characterized hPSC-derived kidney organoids provide the starting point for cyst phenotypes, PKD-related assays, candidate-intervention conditions, QC and deliverables.
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BBB co-culture & permeability methods
Build on HUVEC–astrocyte co-culture and ZO-1 junction imaging, with permeability, candidate-response and transport assays configured for the program.
↗Share your study hypothesis, available samples and priority endpoints; our scientists will recommend a suitable model and collaboration approach.
Tell us about your candidate, sample context and program priorities; our scientists will recommend the model, assay panel and study plan.