Biobank中文Project inquiry
R&D ServicesNavigation menu
R&D ServicesModels & ProductsApplicationsTechnologyEvidence & ResourcesHow We WorkAbout TRiCBIONews & EventsBiobankProject inquiry中文

Solutions & R&D services

Disease models for collaborative research

Use established IBD assay methods or tailor ADPKD, blood–brain barrier and other disease models for mechanistic research and scientific collaboration.

Research collaborationView all services ↗
Discovery & validationSafety & drug deliveryDisease models

Discovery research

Discovery & validation

Screen or perturb targets in relevant human models, then examine phenotype and pathway changes.

4 services
Organoid target discovery connecting genetic perturbation, molecular confirmation, functional phenotype and treatment responsePDO 1.0 + PDO 2.0 · genetic-library screening01

Organoid target discovery & functional genomics

Discover genetic dependencies through library screening in PDO 1.0 and PDO 2.0. Validate targets through tumor, microenvironment and treatment-response readouts.

↗Organoid target-validation workflow from model selection and delivery through genetic perturbation, molecular confirmation and functional phenotyping02

Target validation & mechanism studies

Test candidate targets in human organoids through disease phenotypes, molecular changes and treatment response.

↗H&E histology and CD31/HEP-1 immunohistochemistry in HCC source tissue and PDOHCC tissue & PDO · H&E, CD31 & HEP-103

Mechanism & biomarkers

Link tissue, functional and molecular results to treatment response and prioritize biomarker candidates for validation.

↗Two GIST morphology groups comparing tissue-derived cultures, source-tissue H&E and culture H&E04

Custom model development

Develop a model and assay plan for specialized tissues, rare diseases or complex co-cultures, starting from the samples and endpoints available to your program.

↗

Safety & drug delivery

Safety & drug delivery

Examine in vitro injury-response windows, with barrier or transport assays where the study calls for them.

1 service
Bright-field and FITC microscopy in control and inflammation-challenged human intestinal organoidsHuman intestinal organoid · inflammation & barrier01

Drug delivery & barrier permeability

Assess barrier integrity, injury and repair, then develop permeability or candidate-transport assays for the relevant tissue system.

↗

DISEASE MODELS

Disease models for collaborative research

Start with inflammatory barrier biology, inherited kidney disease or neurovascular-barrier questions, then use model characterization to guide mechanism studies, method development or custom conditions.

View all disease models ↗
Barrier and IL-8 quantitative readouts in a human intestinal organoid IBD-like inflammation model
01Tailored studies

Human intestinal organoid IBD-like inflammation model

Study IBD-like inflammation in human intestinal organoids through morphology, FITC-Dextran, IL-8 and image-based candidate readouts.

↗E-cadherin, LRP2 and Nephrin immunofluorescence in H9-derived kidney organoids
02Custom model development

Tailored ADPKD organoid cyst-phenotype studies

Develop cyst-phenotype and candidate-intervention studies for autosomal dominant polycystic kidney disease (ADPKD), starting from characterized hPSC-derived kidney organoids.

↗ZO-1, DAPI and merged immunofluorescence in the BBB co-culture system
03Custom model development

BBB co-culture & permeability methods

Build on HUVEC–astrocyte co-culture and ZO-1 junction imaging, with permeability, candidate-response and transport assays configured for the program.

↗
Need a different tissue, stimulus or co-culture design?

Share your study hypothesis, available samples and priority endpoints; our scientists will recommend a suitable model and collaboration approach.

Discuss a disease-model study
Not sure where to start?

Tell us about your candidate, sample context and program priorities; our scientists will recommend the model, assay panel and study plan.

Discuss the study objective